Extended Data Fig. 2: PPB tumor cells exhibit reduced levels of proliferation in vitro and in vivo.
From: PI3Kβ controls immune evasion in PTEN-deficient breast tumours
a, Cell proliferation in vitro under reduced serum/nutrient conditions. Data shown as mean and s.d. (n = 6 biological replicates per condition). b–c, Analysis of GFP-tagged PP, PPA and PPB tumors harvested five days after tumor cell transplantation into nude mice. Representative sections (b) and quantification (c) are shown (n = 6 tumors for PP and PPB; n = 3 tumors for PPA). GFP was added via lentiviral transduction in vitro prior to transplantations. Scale bars: 100 μm (left) and 50 μm (right). Box plots represent median and inter-quartile range, and min-to-max error bars (whiskers). For comparison of multiple mean values (a and c), one-way ANOVA followed by Tukey’s multiple comparisons tests.
