Extended Data Fig. 10: Examples of balanced chromothripsis events in cancer genomes.
From: Mitotic clustering of pulverized chromosomes from micronuclei
a) Example of a canonical chromothripsis event affecting the q-arm of chromosome 22 in liver hepatocellular carcinoma exhibiting the characteristic pattern of DNA copy number oscillations (indicated by the red arrows). b–f) Additional examples of balanced chromothripsis events detected in liver cancer (b–c), glioblastoma (d), melanoma (e), and prostate adenocarcinoma (f). g–h) Examples of balanced chromothripsis events causing inactivation of PTEN (g) and generating a TMPRSS2-ERG gene fusion (h) in prostate adenocarcinomas.
