Extended Data Fig. 6: HLA-B*15:01 interaction with peptides derived from SARS-CoV-2 and seasonal coronaviruses.
From: A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection
(a–b) Structures of HLA-B*15:01-NQK-Q8 (peptide as purple sick) (a) and HLA-B*15:01-NQK-A8 (peptide as orange stick) (b), with the HLA chain in white cartoon. (c–d) Electron density map around the NQK-Q8 (purple stick) and NQK-A8 (orange stick) peptides, respectively, in green at 3s for the Fo-Fc map. (e–f) Electron density map around the NQK-Q8 (purple stick) and NQK-A8 (orange stick) peptides, respectively, in blue at 1s for the 2Fo-Fc map. (g–h) Bfactor analysis of the atoms of the NQK-Q8 and NQK-A8 peptides, respectively. The atoms are coloured according to their Bfactor that indicates the mobility of each atom from low (blue) to high (red).
