Fig. 3: Details of the interface between the Rpd3S complex and the H3K36me3 nucleosome.
From: Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S
a, A model of the core Rpd3S complex bound to the H3K36me3 modified nucleosome following histone H4 deacetylation. Interactions are outlined and shown in close up in the indicated panel. b, Detailed view of the location between the N terminus of H4 and Rpd3 in the close state as shown in a. c, Detailed view of the interactions between CHD and the H3K36me3 modified nucleosome as shown in a. The residues of CHD and the nucleotides of nucleosomal DNA involved in recognition and H3 tail residues are shown as sticks. Selected hydrogen bonds are shown as red dashed lines. d, Detailed view of interactions between the Rco1 MID and linker DNA of nucleosome as shown in a. Residues at the interface are depicted as sticks. e, Detailed view of interactions between Sin3 and nucleosomal DNA at SHL +2.5 as shown in a. The residues of Sin3 and the nucleotides of nucleosomal DNA involved in recognition are shown as sticks. Selected hydrogen bonds are shown as red dashed lines.
