Extended Data Fig. 3: Detailed structure of the Rpd3S complex.
From: Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S
a. A cartoon model of Rpd3S complex shown in two different views. PAH, paired amphipathic helice; HID, HDAC-interaction domain; αβC, “α-β-coil” motif; PHD, plant homeobox domain ; MID, MRG-interacting domain; SBD, Sin3-binding domain. b. The interactions between the core enzyme Rpd3 and its neighboring subunits are shown. Acidic residues of the α1 of Sin3 pack against the basic surface of the Rpd3. The negatively charged residues are shown as sticks. c. Sequence conservation analysis of the α1 of Sin3 from yeast to human.
