Extended Data Table 3 Ligands-induced GRK2 recruitment to NTSR1

From: GPCR activation and GRK2 assembly by a biased intracellular agonist

  1. Data represent mean Span (Span ± S.D.). Span is equal to the high concentration response minus the low concentration response. The high and low concentration of NTS are 1 μM and 0 μM. The high and low concentration of SBI-553 are 25 μM and 0 μM. Data were generated and graphed as means ± S.D. of at least three independent experiments (n ≥ 3) performed in duplicate. Statistical significance of differences between WT and mutants was determined by two-sided one-way ANOVA. *P < 0.05, **P < 0.01 and ***P < 0.001 versus WT.
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