Fig. 3: Genetic basis of immune responses to RNA viruses.
From: Dissecting human population variation in single-cell responses to SARS-CoV-2
a, The number of eQTLs detected per gene within each immune lineage. b, Comparison of reQTL effect sizes (β) between SARS-CoV-2- and IAV-stimulated cells. Each dot represents a specific reQTL (that is, SNP, gene and lineage) and its colour indicates the lineage in which it was detected. c, The number of virus-dependent reQTLs (two-sided Student’s t-test nominal interaction, P < 0.01) in each immune lineage, coloured according to the lineage and the stimulus for which the reQTL has the largest effect size. d, Example of a SARS-CoV-2-specific reQTL at MMP1. P values (P < 0.01) calculated using Student’s two-sided t-tests are shown. The centre line shows the median; the notches show the 95% CIs of the median; the box limits show the upper and lower quartiles; the whiskers show 1.5× interquartile range; and the points show outliers. e, Enrichment in eQTLs among genes that are differentially expressed between populations (popDEGs). For each immune lineage, the bars indicate the percentage of genes with a significant eQTL, at the genome-wide scale and among popDEGs, before or after adjustment for cellular composition. f, For each lineage and stimulus, the x axis indicates the mean contribution of either genetics (that is, the most significant eQTL per gene in each lineage and stimulus) or cellular composition to population differences in expression, across all popDEGs (top) or popDEGs associated with an eQTL (bottom). The size of the dots reflects the percentage of genes with a significant mediated effect at an FDR of 1% (Supplementary Table 6). The number (n) of independent biological samples is indicated where relevant.
