Extended Data Fig. 7: Polar interactions between extra membranous S4 and ICHs and the CNBDs.
From: Structure and electromechanical coupling of a voltage-gated Na+/H+ exchanger
top: Cartoon representation of the SLC9C1 homodimer, with the NHE transporter (grey), VSD domains (teal) and CNBD (browns) and connecting intracellular helices ICH1-ICH4 (orange) and ICH5-ICH7 (purple). bottom-left: left, zoomed in view highlighting the polar interactions (1) between the start of the extra membranous region in S4 (teal-sticks) with ICH6 and the start of ICH7 (purple sticks). Yellow dashed-lines show salt-bridge and hydrogen-bonding interactions up to 4 Å. bottom-right, zoomed in view highlighting the polar interactions (2) between the cytoplasmic end of the extra membranous region in S4 (teal sticks) with ICH3 (orange-sticks), ICH5 (purple-sticks) and CNBD helices (brown-sticks). Yellow dashed-lines show salt-bridge and hydrogen-bonding interactions up to 4 Å.
