Extended Data Fig. 6: Proportion of protein assays that have a cis pQTL for subgroups of proteins defined by protein dilution, protein cellular location and overlap between platforms.
From: Large-scale plasma proteomics comparisons through genetics and disease associations
The plot show point estimates with 95% confidence interval. Centre points show proportion of cis pQTLs in each group. Top left panel based on 1964, 526, 257, 127 and 72 proteins with dilutions 1:1, 1:10, 1:100, 1:1000, and 1:1000 dilution, respectively. Top right panel based on 3981, 778 and 148 proteins with dilutions 1:5, 1:200 and 1:20000, respectively. Bottom left panel based on 1409 intracellular, 839 membrane and 698 secreted Olink proteins (red points); and 2419 intracellular, 1434 membrane and 1054 secreted SomaScan proteins (blue points). Bottom right panel based on 1100 Olink proteins non-overlapping and 1846 Olink proteins overlapping with SomaScan (red points); and 2951 SomaScan proteins non-overlapping and 1956 SomaScan proteins overlapping with Olink (blue points).
