Extended Data Fig. 5: Significance of pQTLs and effect of alternative allele.
From: Large-scale plasma proteomics comparisons through genetics and disease associations
Top: significance of detected pQTLs in the UKB-BI and Iceland 36K data sets. For all platforms and populations, at the population size, a relatively much higher number of trans pQTLs than cis pQTLs have significance close to the threshold. p-values were based on two-sided significance tests and not corrected for multiple comparsions. Bottom: Effect of alternative allele broken down by presence or absence of PAV or cis eQTL in high LD. PAV-M: moderate impact PAV, PAV-H: high impact PAV, n_O: number of cis pQTLs detected with Olink, n_S: number of cis pQTLs detected with SomaScan. Box plots show the median and lower and upper quartiles; whiskers extend to 1.5 times the interquartile range; points beyond whiskers are plotted individually.
