Extended Data Fig. 8: Portability of an MCPS (N=119,864) derived BMI PRS to UKB (N = 443,145) individuals.
From: Genotyping, sequencing and analysis of 140,000 adults from Mexico City
In panel A, the MCPS PRS accuracy is measured using the incremental R2 between the BMI PRS and measured BMI (kg/m2) in UK Biobank individuals, stratified by 1000 Genomes-based continental ancestry (red = African [N = 8025], lime green = East Asian [N = 2110], green = European [N = 424,283], blue = Latino [N = 590], purple = South Asian [N = 8137]). The R2 measures are denoted by a circle (African), triangle (East Asian), rectangle (European), dash (Latino), and dotted rectangle (South Asian), with vertical bars denoting the 95% confidence interval. The BMI values used in PRS derivation were transformed (RINT by sex, ancestry PCs) and adjusted for age and age2. Panel B displays the change in BMI per BMI PRS standard deviation (SD) using the same color scheme based on 1000 Genomes-based continental ancestry, with the shapes denoting the mean BMI change (circle [African], triangle [East Asian], rectangle [European], dash [Latino], and dotted rectangle [South Asian] and vertical bars denoting the 95% confidence interval. BMI Regression models were adjusted for sex, age, age2, and ancestry PCs.
