Fig. 3: Associations between local ancestry at fine-mapped MS-associated SNPs and MS in a modern population.
From: Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
a, Risk ratio of SNPs for MS based on WAP (see Methods) when decomposed by inferred ancestry. The mean and s.d. were calculated for each ancestry on the basis of bootstrap resampling for each chromosome (n = 408,884 individuals). The distribution of risk ratios for each ancestry is shown as a raincloud plot. SNPs significant at the 1% level are shown individually, coloured by chromosome or HLA region, and those with a risk ratio of >1.2 or <0.8 are annotated with their rsID, HLA region and position (build GRCh37/hg19). b,c, ARS (see Methods) for MS. The mean and confidence intervals were estimated by either bootstrapping over individuals (b; which can be interpreted as testing the power to reject a null hypothesis of no association between MS and ancestry; n = 1,000 bootstrap resamples with replacement over 24,000 individuals) or bootstrapping over SNPs (c; which can be interpreted as testing whether ancestry is associated with MS across the genome; n = 1,000 bootstrap resamples with replacement over 204 SNPs). We show the results for all associated SNPs (red) and non-HLA SNPs only (blue) when bootstrapping over individuals.
