Extended Data Fig. 4: Signatures of selection at the HLA locus showing different regions of the HLA (horizontal coloured bar) and locations of MS-associated SNPs (vertical lines, coloured by the variance explained by 6 ancestries).
From: Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
a): Whole Chromosome 6 “local ancestry” decomposition by genetic position. b). HLA “local ancestry” decomposition by genetic position. c): LDA score; low values are indicative of selection for multiple linked loci, while high values indicate positive selection. d): pi scores (nucleotide diversity) for CEU (Northern and Western European ancestry). MS-associated SNPs fall in highly diverse regions of the HLA. e): Fst scores (divergence between two populations) for CEU vs YRI(Yoruba); locally higher scores indicate regions that have undergone differential selection between the two populations.
