Extended Data Fig. 13: pMHC Cross-Reactivity Algorithm sCRAP Predicts MAGE-A3 toxicity through TITIN.
From: Targeting of intracellular oncoproteins with peptide-centric CARs
a. Table of top predicted cross-reactive peptides to MAGE-A3 peptide EVDPIGHLY reveals cross-reactivity with Titin peptide ESDPIVAQY ranks 4th out of 1,143,861 potential peptides presented on HLA-A*01:01. b. TITIN is highly expressed in GTEx RNA-sequencing of heart (n = 108) and muscle (n = 138) tissues. Lower and upper bounds of boxplot correspond to the first and third quartiles (the 25th and 75th percentiles); whiskers represent minima/maxima or 1.5*IQR.
