Extended Data Fig. 16: Immunohistochemistry of tumors collected from mice exceeding tumor burden.
From: Targeting of intracellular oncoproteins with peptide-centric CARs
COG-564x tumor-bearing mice treated with 10LH and 302LH PC-CARs show T cell infiltration as measured by CD3, co-localized with loss of PHOX2B target expression and tissue necrosis. No evidence of T cell infiltration observed in mice treated with untransduced T cells. Tumors were collected from one of each mouse in treatment arms reaching tumor burden 11 days after receiving T cells. All other mice in treatment arms went on to achieve complete responses. Images shown from tumors collected from lone mice reaching tumor burden each study arm in single experiment.
