Extended Data Fig. 6: Analyses of the interaction between caspase-4 or caspase-3-cleaved IL-18 and IL-18Rα. | Nature

Extended Data Fig. 6: Analyses of the interaction between caspase-4 or caspase-3-cleaved IL-18 and IL-18Rα.

From: Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome

Extended Data Fig. 6

Gel-filtration chromatography analyses of complex formation between the extracellular domain of IL-18Rα and pro-IL-18, mature IL-18, caspase-4-cleaved pro-IL-18 (WT, Δ70-77, or F38D), or caspase-3-cleaved pro-IL-18. SDS-PAGE of the elution fractions are shown when formation of a complex was observed. All data are representative of three independent experiments.

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