Extended Data Fig. 2: Diabetes associated susceptibility to respiratory viral infection is associated with broadly impaired adaptive immunity in streptozotocin-induced diabetes.

a, Blood glucose, PBS (n = 20) or STZ (n = 16) administered mice, analyzed at 10 d.p.i., two-sided unpaired t-test. b, Survival, PBS (n = 10) or STZ (n = 10) administered mice, log-rank Mantel-Cox test. c-r, Mice infected with 50pfu PR8, administered PBS (n = 20) or STZ (n = 10 in e, n = 9 in all other panels), analyzed at 10 d.p.i. c, Lung Ifnβ1, two-sided Mann-Whitney U-test. d-e, Lung histology, d, representative sections, e, inflammatory score, two-sided Mann-Whitney U-test. f, Lung T cells, two-sided unpaired t-test. g-h, Flow cytometry,lung T-bet⁺CD8⁺ T cells, g, representative blots h, quantification, two-sided unpaired t-test. i, Lung IFNγ⁺CD8⁺ T cells, two-sided unpaired t-test. j, Lung Ki-67⁺CD8⁺ T cells, two-sided unpaired t-test. k, Lung FoxP3⁺CD4⁺ T cells, two-sided Mann-Whitney U-test. l, Lung B cells, two-sided Mann-Whitney U-test. m-n, Flow cytometry, GC B cells, m, representative blots, n, quantification, two-sided Mann-Whitney U-test. o-p, Virus specific IgG2b,o, BAL, p, serum, two-sided unpaired-test for EC50. q-r,Virus specific IgM, q, BAL, r, serum, two-sided Mann-Whitney test for EC50. All data mean+s.e.m.