Extended Data Fig. 12: Conserved cis-regulatory landscape of disease risk.
From: Conserved and divergent gene regulatory programs of the mammalian neocortex
a. A violin plot showing conservation index of cCREs containing fine-mapped disease-risk variants in Alzheimer’s disease, bipolar disorder, and schizophrenia. Width of violin plots represent the density of data points. Box plots encompass 25th to 75th percentiles; lines inside the boxes represent medians; whiskers represent 1.5 times the interquartile interval. N = 384,412 (All cCREs), 86 (Alzheimer’s disease), 49 (Bipolar disorder), 251 (Schizophrenia). Two-sided, unpaired Wilcoxon rank sum test for P-values vs “All cCREs”. b. Genome browser snapshot showing H3K27ac landscapes of a mammal level 2 predicted enhancer of ELMO1 overlapping a multiple sclerosis risk variant across cell types.
