Fig. 3: Comparative analysis of DNA methylomes across species.
From: Conserved and divergent gene regulatory programs of the mammalian neocortex
a, The conservation levels of human DMRs, including human-specific (sequence divergent), level 0 (sequence conserved), level 1 (tissue conserved), level 2 (cell type conserved) and level 3 (matched patterns across all cell types) across mammals. b, The relationship between the conservation index (mean GLS T-statistic across comparisons) of chromatin accessibility, and the conservation index of DNA methylation for intersecting ATAC–seq peaks and DMRs. P values were calculated using two-sided Spearman correlation. c, The percentage of human DMRs in TEs for different conservation groups. d, Comparison of the average conservation index of DMRs and ATAC–seq peaks containing a particular motif from the JASPAR CORE database. Motifs are coloured by TF class annotation.
