Fig. 7: Taking advantage of epigenetic conservation to interpret non-coding risk-associated variants of neurological disease and traits.
From: Conserved and divergent gene regulatory programs of the mammalian neocortex
a, Linkage disequilibrium score regression analysis to identify GWAS enrichments in cCREs of each cell type for different conservation sets. *FDR-adjusted P < 0.001, **FDR-adjusted P < 0.0001, ***FDR-adjusted P < 0.00001. b, The distribution of LDSC enrichments across cells for each of the 25 traits from a. c, The distribution of LDSC enrichments across cells for MS, anorexia nervosa and tobacco-use disorder. d, The top significant GO biological process terms for ABC target genes of enhancers containing a MS-associated risk variant63. e, Example locus of a mammal level 2 predicted enhancer of ELMO1 overlapping a MS-associated risk variant in a microglia-specific chromatin-accessible region.
