Extended Data Fig. 8: Comparison of Tad2 and Tad1 in the apo and ligand-bound states.
From: Phages overcome bacterial immunity via diverse anti-defence proteins
(a) Overview of the crystal structure of SPO1 Tad2 in the apo state in front and top view. (b,c) Overview and detailed binding pocket views of adenine interactions (left) and ribose/phosphate interactions (right) of the crystal structures of SPO1 Tad2 in complex with 1″–3′ gcADPR (b) or 1″–2′ gcADPR (c). (d) Overview of the crystal structure (PDB: 7UAV) of cbTad1 in the apo state in front view and top view. (e,f) Overview and detailed binding pocket views of adenine interactions (left) and ribose/phosphate interactions (right) of the crystal structures of cbTad1 in complex with 1″–3′ gcADPR (e) or 1″–2′ gcADPR (f, PDB: 7UAW).
