Fig. 1: An overview of the workflow and microbial SV data.
From: Host genetic regulation of human gut microbial structural variation
a, The workflow of this GWAS on gut microbial SVs. In this study we integrated data for 9,015 individuals from whom both gut microbial metagenomic and host genetic data are available from four cohorts. Data from a Tanzanian cohort of 279 individuals were included as a replication cohort. We generated gut microbial SV profiles based on metagenomic sequencing, with the dSVs and vSVs then subjected to association analysis with the genotypes of more than 6 million common SNPs in the human genome. The genetic associations are presented in box plots for vSVs, bar plots for dSVs and Manhattan plots for the whole-genome level. Created with BioRender.com. b, The number of common microbial SVs detected in 49 species for GWAS. Each bar represents a species. The y axis refers to the number of common SVs detected in that species. dSVs and vSVs are coloured in green and blue, respectively. c, A pie chart of the 3,552 common SVs, including 1,666 dSVs and 1,886 vSVs, involved in the GWAS.
