Extended Data Fig. 5: Population genetic structure of F. prausnitzii and its association with ABO-associated SVs.
From: Host genetic regulation of human gut microbial structural variation
a, The x-axis and y-axis show the top two PCs. Each dot represents a sample. In each panel figure, dots are colored differently based on the presence/absence status of dSVs or the standardized coverage of vSVs following the color key shown in the figure. The significance of associations between population genetic structure of F. prausnitzii and SVs was estimated by permutational multivariate analysis of variance (PERMANOVA), and all associations for the five ABO-associated SVs are significant (unadjusted P < 0.05). b, Association of F. prausnitzii abundance with ABO blood groups in the DMP cohort. Species abundance (CLR-transformed) of F. prausnitzii (y-axis) plotted against ABO-encoded blood groups for all DMP individuals (x-axis). Violin plots show density distribution, whereas the inner boxplots represent summary statistics: the center line is the median, the box hinges are the lower and upper quartiles of the distribution, the whiskers extend no further than 1.5× interquartile range from the hinges, and data beyond the end of the whiskers are outliers plotted as individual points. Unadjusted P-value reflects the significance of association of ABO blood groups (A/AB vs B/O) with F. prausnitzii abundance after adjusting for covariates assessed using linear mixed models.
