Fig. 5: Comparison of GalNAc associations between two groups of individuals with or without mucosal A-antigen.
From: Host genetic regulation of human gut microbial structural variation
a,b, Comparison of the abundance of GalNAc genes, lacC (a) and gatY–kbaY (b), between two groups of individuals (nwithout = 3,866 and nwith = 1,868). The violin plots show ln-transformed gene abundance with units of reads per kilobase million (RPKM). The inner box plots represent summary statistics: the centre line represents the median, the box hinges represent the lower and upper quartiles of the distribution, whiskers extend no further than 1.5× interquartile range from the hinges, and data beyond the end of the whiskers are outliers plotted as individual points. Unadjusted P values are reported, based on linear mixed models. c, Comparison of the correlations of GalNAc metabolism gene abundance with gut microbiome α-diversity and richness between two groups: individuals with mucosal A-antigen (x axis; n = 1,868) and those without (y axis, n = 3,866). Each dot represents a Spearman correlation coefficient between a GalNAc gene with the Shannon index (green) or richness (blue). The error bars indicate the confidence interval of the correlation R estimation based on s.e. d,e, The association between GalNAc metabolism gene abundance and host phenotypes in individuals with (d; n = 1,868) and without (e; n = 3,866) mucosal A-antigens (unadjusted P values are estimated from linear regression). Hash symbols indicate group-specific significant associations. Asterisks indicate significant associations shared by the two groups (Bonferroni-corrected P < 0.05). Exact P values are listed in Supplementary Table 19. Positive associations are in red. Negative associations are in blue. The colour gradients reflect the effect size. BMI, body mass index; BristolType, Bristol stool type; GeneralHealth, general health score; HDL, high-density lipoprotein cholesterol; TG, triglyceride levels.
