Extended Data Fig. 3: Comparison of F. prausnitzii dSV associations between the Dutch and Tanzanian cohorts.
From: Host genetic regulation of human gut microbial structural variation
a, Q-Q plots of the associations between human SNPs and F. prausnitzii SVs in the Dutch cohorts. X-axis is the expected log-transformed P-value. Y-axis is the observed log-transformed unadjusted P-value derived from the linear mixed model. Each dot represents an association P-value. The diagonal is represented by the solid red line. The lambda (λ) value represents the genomic inflation factor. b, Comparison of the presence/absence ratio of dSVs between the DMP cohort (N = 5044) and the Tanzanian cohort (N = 201). Bar plots show the fraction of samples with (dark blue) or without (cyan) the dSV region. c, Association of F. prausnitzii dSV 575–577 with rs550057 in both the Dutch and Tanzanian cohorts. Bar plots show the number of samples with (dark blue) and without (cyan) the dSV region per genotype. The P-value indicates the unadjusted association significance assessed by fastGWA using linear mixed models. d, Association of F. prausnitzii 577–579 with rs1633513 in both cohorts. Bar plots show the number of samples with (dark blue) and without (cyan) the dSV region per genotype. The P-values indicate the unadjusted association significance assessed by fastGWA based using linear mixed models.
