Extended Data Fig. 5: Independent validation of new conjugated bile acids in PRISM human IBD cohort.
From: Reverse metabolomics for the discovery of chemical structures from humans
a) Peak area abundances of conjugated bile acids detected in longitudinal PRISM dataset10. Boxplots show first (lower) quartile, median, and third (upper) quartile and whiskers are 1.5 times the interquartile range. n for Crohn’s disease (CD) = 68, n for non-IBD = 34 and n for ulcerative colitis (UC) = 53. b) Peak area abundances of selected bile acids that were higher in Crohn’s and/or Ulcerative Colitis patients relative to non-IBD individuals, as determined by pairwise two-sided Wilcoxon tests. Only significant values are shown, which were calculated using a Benjamini-Hochberg correction. Boxplots show first (lower) quartile, median, and third (upper) quartile and whiskers are 1.5 times the interquartile range. n for CD = 68, n for non-IBD = 34 and n for UC = 53.
