Fig. 1: Examples of state-of-the-art remote functionalization reactions of alkenes. | Nature

Fig. 1: Examples of state-of-the-art remote functionalization reactions of alkenes.

From: Stereodivergent 1,3-difunctionalization of alkenes by charge relocation

Fig. 1

a, Current paradigm for the distal functionalization of alkenes, relying on directing-group-mediated metal catalysis. b, Friedel–Crafts-type reactions of alkenes generally provide mixtures of products—which depend on the substrate, reagent and solvent—with selectivity observed only with specialized substrates. c, This work: stereodivergent, reagent-controlled 1,3-difunctionalization of alkenes through charge relocation. DG, directing group; Bpin, pinacol boronate.

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