Extended Data Fig. 4: OFL-related neuronal activation, dmPFC→l/vlPAG or dmPFC→BLA collaterals. | Nature

Extended Data Fig. 4: OFL-related neuronal activation, dmPFC→l/vlPAG or dmPFC→BLA collaterals.

From: A distinct cortical code for socially learned threat

Extended Data Fig. 4

a, Assessing OFL-related neuronal activation in CTB-labelled dmPFC→l/vlPAG and dmPFC→BLA neurons. b, c-fos-positive and CTB-positive dmPFC→l/vlPAG (left) and dmPFC→BLA (right) neurons. c, Percent c-fos-positive/CTB-posiitive dmPFC→l/vlPAG (n = 5 mice) and dmPFC→BLA (n = 7 mice) neurons in OBS. d, Synaptophysin expression in dmPFC (left), l/vlPAG (centre, upper) and BLA (centre, lower). Regions exhibiting synaptophysin expression (right upper and lower). e, Regions receiving collaterals from dmPFC→l/vlPAG neurons. f, Regions receiving collaterals from dmPFC→BLA neurons. Abbreviations (based on Paxinos and Franklin atlas, 5th edition): AI; agranular insula, Aq; aqueduct, CL; centrolateral thalamus, CLA; claustrum, DLS; dorsolateral striatum, DMS; dorsomedial striatum, lPAG; lateral periaqueductal gray, LH; lateral hypothalamus, LHb; lateral habenula, MD; mediodorsal thalamus, MHb, medial habenula, PH; posterior hypothalamus, ZI; zona incerta, vlPAG; ventrolateral periaqueductal gray, V3; 3rd ventricle. Data shown in c are means ± SEM.

Source Data

Back to article page