Extended Data Fig. 8: Superbinder Staphylococcus show highly overlapping sub-networks. | Nature

Extended Data Fig. 8: Superbinder Staphylococcus show highly overlapping sub-networks.

From: A host–microbiota interactome reveals extensive transkingdom connectivity

Extended Data Fig. 8

a, Network of 7S. pasteuri and 8 other Staphylococcus superbinders, highlighted in green and orange respectively. The 5 proteins bound by the most strains are labeled. b, Overlap in interaction profiles across strains. Proteins are binned according to whether they are bound by more than half of the S. pasteuri strains (“Pasteuri core”), or by multiple or only one superbinder strains (“Multiple” and “Unique”, respectively). c, Top proteins bound by multiple superbinders. Overall interaction profiles of proteins bound by 7 or more superbinder strains are colored according to the strains they recognize, including all other Staphylococcus strains as well as non-Staphylococcus strains. d, Interactions for skin-expressed proteins CDSN, FAT2, and XG for all 519 bacterial strains organized by tissue of origin. Dashed red line at 0.5 represents hit threshold.

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