Extended Data Fig. 9: The interaction of nascent RNA with Rat1 in Pol II Rat1-PTTC1.
From: Structural basis of exoribonuclease-mediated mRNA transcription termination
a, The interaction between the 5′ phosphate groups of the first two nucleotides with the active site of Rat1. Black dash, the coordination bonds. Blue dash, the H-bonds. b, The interaction of nascent RNA with Rat1 and Pol II. The cryo-EM map for the RNA-contacting residues is shown in blue. C, The modeled triphosphate group of the RNA 5′ terminus clashes with Rat1. Left, RNA with a monophosphate group in the structure of Pol II Rat1-PTTC1; right, RNA with a modeled triphosphate group in the structure of Pol II Rat1-PTTC1.
