Extended Data Fig. 12: Epigenetic changes evoked in human CAR T cells by FOXO1 overexpression.
From: FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
a, ChromVAR analysis of motifs (JASPAR) with increased or decreased accessibility in FOXO1-expressing CAR T cells. Heatmap depicts the top 20 motifs in each direction for non-stimulated cells and the same motifs after CAR activation. b, fold reduction in indicated transcription factor expression following FOXO1 overexpression in CD8+ CAR T cells analyzed as per Fig. 3e. c, Location of peaks with reduced accessibility in FOXO1-expressing T cells relative to controls prior to stimulation (left) and after MCF7 coculture (right). Source data are provided in the Source Data file.
