Extended Data Fig. 2: HPO-27 is homologous to human MROH1.
From: The HEAT repeat protein HPO-27 is a lysosome fission factor
a, Sequence alignment of C. elegans (c.e) HPO-27 and human (h.s) MROH1. Identical residues are shaded in black. The red box indicates the disordered region and blue boxes designate the HEAT motifs. b, The percentage of worms with diminished NUC-1::CHERRY fluorescence was quantified in the indicated strains at adult day 3 (n = 50 worms in each of 3 biological repeats for each strain). Data are shown as mean ± SD. One-way ANOVA with Tukey’s multiple comparison test was performed to compare mutant datasets with WT or datasets that are linked by lines. P values are indicated.
