Extended Data Fig. 6: EP2/EP4 double deficiency permits clonal differentiation and expansion of CD8+ TILs in PGE2-producing tumours.
From: PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
a, UMAP visualisations of T cell clonotype distribution across CD8+ TILs based on scTCR-seq. b, Clonotype frequency across CD8+ TIL clusters based on a. c, UMAP visualisation of expanded tumour-infiltrating CD8+ T cell clonotypes coloured according to cluster classification. d, Comparison of clonotype frequencies between Ptger2−/−Ptger4fl/fl, Cd4crePtger2−/−Ptger4fl/fl and GzmbcrePtger2−/−Ptger4fl/fl mice. e, Frequencies of T cell clones shared between TCF1+CD8+ TILs and TIM-3+ TIL progeny. f, UMAP plots visualising the top 3 most frequent shared clonotypes for Ptger2−/−Ptger4fl/fl, Cd4crePtger2−/−Ptger4fl/fl and GzmbcrePtger2−/−Ptger4fl/fl mice. Data are from one experiment.
