Extended Data Fig. 2: Cd4crePtger2−/−Ptger4fl/fl mice reject PGE2-producing tumours.
From: PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
Growth profiles following s.c. inoculation of cancer cell lines into WT, Ptger2−/−Ptger4fl/fl or Cd4crePtger2−/−Ptger4fl/fl mice. a, Individual profiles of 2 × 105 control or Ptgs1/Ptgs2−/− BRAFV600E tumour cells (n = 10). b, Growth of 2 × 105 Ptgs1/Ptgs2−/− BRAFV600E melanoma cells transplanted into Rag1−/− mice (n = 4) or WT mice with or without CD8+ T cell depletion (n = 5 per group). c, Individual profiles of 2 × 106 Panc02 tumour cells (n = 8). d, Individual profiles of 2 × 105 MC38 tumour cells (n = 6). e, Representation of all profiles shown in d. Data in a-e are pooled from two (b,c,d,e) or three (a) independent experiments and depicted as mean ± s.e.m. P values are from two-way ANOVA with Bonferroni’s multiple-comparison test. P ≥ 0.05, not significant (NS).
