Extended Data Fig. 7: UH15-38 does not impede virus clearance or anti-IAV CD8+ T cell responses.
From: Necroptosis blockade prevents lung injury in severe influenza
a,b, Lung morphometry showing virus spread (red areas) in lungs (a) and quantitation of percentage of viral antigen-positive lung area (b) at 6 days after infection. n = 5/group. c, Virus titers in lungs (day 3 and day 6, n = 10/group; day 9 and day 12, n = 5/group) at indicated time points as determined by plaque assay. d, Frequencies of IAV-specific CD8+ T cells nine days after infection with PR8 in BALF of vehicle- and UH15-38-treated mice using peptide:MHC tetramers incorporating PB1 residues 703-711 or PA residues 224-233 (n = 10/group). Comparison between groups was carried out by the two-sided Mann-Whitney U test (as in b, c, d), nd = not detected.
