Extended Data Fig. 5: Time course of WRN degradation and DNA damage induction after HRO761 treatment.
From: Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers
Immunoblots for WRN, pATM (S1981), pCHK2 (T68), total CHK2, phospho-KAP1 (S824), pCHK1 (S345), total CHK1, pATR (Y1989), p21, γH2AX and actin during 0.25 h to 24 h of treatment of HCT116 cells with HRO761 at the concentrations indicated. Images from a representative experiment of n = 3.
