Extended Data Fig. 6: Cryo-EM structures of FLVCR1 determined in a substrate-free condition.
From: Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1
a-b, Cryo-EM density maps and atomic models of FLVCR1 in endogenous choline (a) and endogenous ligand-bound (b) states. c-d, Central slice of the central cavity of choline-bound (c) and endogenous ligand-bound (d) states, with surface colored white. Choline is shown as sticks in c. Endogenous ligand is not modeled or shown in d. e, Superposition of choline-bound (grey) and endogenous choline-bound (blue) states. f, Superposition of substrate-binding sites in choline-bound (grey) and endogenous choline-bound (blue) states.
