Extended Data Fig. 4: Choline-bound FLVCR1 adopts an inward-facing conformation.
From: Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1
a, Superposition of TM1-6 and TM7-12. RMSD = 3.5 Å. b, Central cavity viewed from the cytosolic side. Aspartate and glutamate residues in and near the entrance to the central cavity are shown as sticks. c, Central section of choline-bound FLVCR1 is contiguous with choline shown as sticks. d, Blue spheres depict the minimum radius of the central cavity in the choline-bound state as a function of position. e-f, Superposition of choline-bound FLVCR1 (blue) with E. coli SotB (D; PDB: 6KKL; RMSD = 2.3 Å; red) (e) or E. coli DgoT (E; PDB: 6E9N; RMSD = 2.6 Å; cyan) (f).
