Extended Data Fig. 7: Sequence logos of candidate antibody designs.

a, The set of 376 designed IgG includes mutation at 16 positions in the heavy chain (blue; mutations in green) and 9 positions in the light chain (magenta; mutations in pink). Height of each letter is proportional to the frequency of the amino acid in the group. b, c, This set of 376 sequences is divided into two overlapping sets, Set 1 (b; n = 230) and Set 2 (c; n = 204). d, From these two sets, a set of eight sequences was selected for production at larger scale and further evaluation including assessment of their thermostability and binding performance (Fig. 2). Selected sequences show reduction in mutations throughout the CDRH3 residues (103-118) mutated in (a), especially in residues 103-108.