Fig. 3: Designed antibodies improve pseudoviral neutralization over COV2-2130.
From: Computationally restoring the potency of a clinical antibody against Omicron
a–e, The parental COV2-2130 antibody (orange circles), the cross-reactive positive control antibody S2K146 (magenta squares), the negative control antibody DENV-2D22 (grey x) and down-selected computationally designed antibodies (symbols as indicated in the key) were assayed by neutralization with lentiviruses pseudotyped with spike variants of WA1/2020 D614G (a), Omicron BA.1 (b), Omicron BA.1.1 (c), Omicron BA.2 (d) and Omicron BA.4 (e). Curves are four-parameter logistic regression models fit to two (a–d) or four (e) replicate serial dilutions using GraphPad Prism.
