Fig. 1: The effects of optogenetic inhibition on WM task performance.
From: Volatile working memory representations crystallize with practice
a, The experimental set-up. b, The delayed-association WM task trial types; licking was assessed during the 3 s choice period, with early- and late-delays periods noted. c, Learning progress across eight sessions, measured on the basis of the percentage of correct responses. d, Learning session example, with licks marked. e, Photoinhibition effect during different task epochs on the animal’s performance (fourth second of the delay period, P = 0.009; fifth second of the delay period, P = 0.005; second odour, P = 0.0004; first second of choice epoch, P = 0.0001). Statistical analysis was performed using paired t-tests. f, Photoinhibition of the M2 during the last 2 s of the delay period across the first 7 days of training impairs task performance. n = 4 (stGtACR2-expressing) and n = 4 (mCherry-expressing) mice. The P values determined using two-sample t-tests for sessions 1–10 were as follows: P1 = 0.8425, P2 = 0.4610, P3 = 0.6904, P4 = 0.0724, P5 = 0.0463, P6 = 0.0146, P7 = 0.0161, P8 = 0.7065, P9 = 0.6530 and P10 = 0.7955. For c, e and f, data are mean ± s.e.m. NS, not significant; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Details of the statistical analyses are provided in the Methods.
