Extended Data Fig. 7: Nascent Chimeroid input to aggregation steps is composed of expected cell-type populations.
From: Brain Chimeroids reveal individual susceptibility to neurotoxic triggers
a, UMAP of integrated dataset containing DIV23 organoids from our reference map of Velasco-protocol organoid development (“Ref. Map”), and MD-NSC and MD-NPC-Chimeroids 1 day after aggregation (INPUT), colour-coded by annotated cell type. b. UMAPs split by protocol. c, UMAP of the INPUT for MD-NSC Chimeroids (mix 2), colour-coded by annotated cell type. d, UMAPs split by donors. e, UMAP of the INPUT for MD-NPC Chimeroids (Mix 6), colour-coded by annotated cell type. f, UMAPs split by donors. g, Donor demultiplexed after sc-RNA-seq. h, Bar plots of cell-type proportions in INPUT MD-NSC and MD-NPC Chimeroids for each donor. Some icons were created using BioRender.
