Fig. 3: Structures of V-ATPases imaged in wild-type ISVs.
From: Structure and topography of the synaptic V-ATPase–synaptophysin complex
a,b, Atomic models of the V-ATPase–synaptophysin complex imaged in wild-type ISVs. The intact (a; state 3) and V0-only (b) V-ATPase assemblies are shown. The V-ATPase subunits are coloured as indicated, and synaptophysin is coloured in orange. The background grey arc represents the ISV membrane density. Scale bar, 5 nm (the same scale bar is used in a and b). c, Interface (black circle) between V-ATPase subunits e2, a and synaptophysin (the structure of the V0-only V-ATPase assembly of wild-type ISVs). The electrostatic surface potential of this interface is also shown along with an ‘open book’ view. The blue and green circles highlight the interface between synaptophysin and V-ATPase subunit e2 and a, respectively. The interface area is approximately 350 Å2.
