Extended Data Fig. 10: Increased IFN in SLE patients inhibit AHR signaling.
From: Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus
a, IFN signature score in RNA-seq data of CD4+ T cell subsets from SLE and control patients as in Fig. 1g. Median ± interquartile range shown. b, Elsevier pathway enrichment from annotated genes of DAR in No IFN-β control treated CD4+ T cells. c, Normalized relative expression of CYP1A1 measured by qPCR in CD4+ T cells cultured in DMSO or TCDD with the addition of vehicle control or IFN-α (n = 8, p = 0.0016 by paired t-test). TCDD = AHR agonist.
