Extended Data Fig. 1: Clinical associations of PD-1+/ICOS+ and CD96hi cell clusters.
From: Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus
a, Differentially expressed proteins on memory CD4+ T cells from SLE patients compared to controls. p-values from t-test with Bonferroni correction. b, Heatmap of marker expression on mass cytometry cell clusters (left) and MASC association statistics for each cluster comparing SLE vs controls (right). SLE OR = odds ratio of representation in SLE vs control. CI = confidence interval. Adj. p-value by FDR. c, Correlation plot of PD-1/ICOS+ cluster and CD96hi cluster abundances in SLE patients and controls. Spearman statistics shown. d, Association of indicated cluster proportions with serum anti-dsDNA antibody level in SLE patients (n = 19). e, Association of indicated cluster proportions with SLE disease activity by SLEDAI-2K (n = 19). f, Association of indicated cluster proportions with prednisone dose or equivalent at time of sample collection. g, Cluster proportions of PD-1+/ICOS+ (left) and CD96hi (right) clusters in SLE patients stratified by immunosuppressant drug use at time of sample collection (no, n = 7; yes, n = 12). Spearman correlation statistics shown in d-f. Boxes in g show median ± interquartile, with bars indicating min/max values within 1.5x interquartile range. Statistics by Mann-Whitney test.
