Fig. 3: Body-wide tissue stress map with cfRNA.

a, Cell-type deconvolution using Bayes Prism with Tabula Sapiens as a reference. Top ten cell types by average fraction across all samples with all remaining cell types summed together as ‘other’. b, Cell type of origin for hepatocytes, endothelial cells, haematopoietic stem cells and melanocytes, which all show increased abundance during post-flight and recovery timepoints. c, Cell proportion changes in different layers of the skin from spatially resolved transcriptomics on skin biopsies. Predicted melanocyte abundance changes are significant in the inner epidermal and outer dermal skin compartments. In panels b and c, n = 4 independent participants across 7 timepoints. The centre of the boxplots represent the median, the box hinges encompass the first and third quartiles, and the whiskers extend to the smallest and largest values no further than 1.5 × IQR away from the hinges. NS, not significant; **P ≤ 0.01; ***P ≤ 0.001.