Extended Data Fig. 7: Fitness experiment of the bla-edited versus non-edited strain in the gut of BALB/c mice.
From: In situ targeted base editing of bacteria in the mouse gut
a) Time-course of the relative abundance of the bla-edited compared to the WT E. coli s21052 strain in 15 mice. Five groups of three mice were treated with independent pairs of clones at an approximate ratio of 1:1 (from 0.92 to 0.96). Plots represent geometric mean and error bars the 95% confidence interval. b) Individual mice data from the same experiment. Colors represent the group of each animal. c) Time-course of the E. coli s21052 colonization level in the streptomycin-treated BALB/c model. Total E. coli bacteria were quantified by plating resuspended stool samples onto Drigalski plates supplemented with streptomycin. Bars represent the median and each dot individual values. d) E. coli s21052 colonization level in the streptomycin-treated BALB/c model for each group. Dots represent the geometric mean, and error bars the geometric standard deviation.
