Extended Data Fig. 8: BASP1+ matPC is involved in tumour angiogenesis.
a. Correlation between the proportion of BASP1+ matPC and APLN+ TipSI. Shaded region represents the 95% confidence intervals. Spearman’s correlation coefficient and its P-value are shown. Dots coloured by cancer types. b. Co-localization between APLN+ TipSI and BASP1+ matPC at spatial positions. Scale bar, 1 mm. c. LR pairs between APLN+/TipSI and BASP1+ matPC. d. Violin plot showing the expression levels of VEGF across PC phenotypes. e. Genome browser view showing the binding of XBP1 and ATF3 in the genome region of VEGFA/VEGFB. ChIP-seq data were obtained from public datasets (XBP1: GSE49952 [BC cell lines: T47D, M231, and HS578T] and GSE157117 [OC cell line: A1847]; ATF3: ENCFF020THR [HCC cell line: HepG2], ENCFF341RJA [human induced pluripotent stem cell: WTC11], and ENCFF561SGX [leukaemia cell line: K562]). f. The median infiltration levels of BASP1+ matPC in each TCGA cancer type across ANT, stage I/II, and stage III/IV samples. GBM was graded by G2, G3, and G4. PRAD was graded by Gleason score (GS). We performed the two-sided Mann–Whitney U test on the mean infiltration levels of BASP1+ matPC between stage I/II and ANT samples in each cancer type. Different stages of the same cancer are connected using coloured lines when P < 0.05. g. Heatmap showing the effects of MC infiltration on OS (right) and PFS (left).
