Extended Data Fig. 9: Cell interactions during tumour angiogenesis.

a. Dot plot showing the LR pairs between TME cells and APLN⁺ Tip^SI when APLN⁺ Tip^SI is a sender (top)/receiver (bottom). b. Circos plot showing the VEGF-VEGFR interactions between vascular cells and TME cells. c. Correlation between the proportion of SPP1⁺ TAM and tip-like VECs. Dots coloured by cancer types. Shaded region represents the 95% confidence intervals. Spearman’s correlation coefficient and its P-value are shown. d. Bar plow showing the number of interactions between SPP1⁺ TAM and tip cells. e. Co-localization among APLN⁺ Tip^SI, SPP1⁺ TAM, MDSC, myoCAF, matCAF, exhausted T cells, and T_reg at spatial positions from ST data of BC (n = 1 case), NSCLC (n = 1 case), PDAC (n = 1 case), OC (n = 1 case), ccRCC (n = 1 case), and cSCC (n = 1 case). Scale bar, 1 mm. f. Representative mIHC of APLN⁺ tip cells and SPP1⁺ TAM in NSCLC from n  =  7 independent biological replicates. Arrows depict the specific cell types.