Extended Data Fig. 10: LR pairs associated with APLN+ TipSI. | Nature

Extended Data Fig. 10: LR pairs associated with APLN+ TipSI.

From: Tumour vasculature at single-cell resolution

Extended Data Fig. 10

a. Spatial plot showing the expression intensity of LR pairs of PAC interactions. APLN+ TipSI can recruit PACs via CD99-PILRA, PGF-/PDGFB-related LR pairs. b. Representative mIHC of PDGFB-expressing APLN+ tip cells and PDGFRB-expressing fibroblasts in CSC from n  =  8 independent biological replicates. Arrows depict the specific cell types. c. Spatial plot showing the expression intensity of LR pairs of Treg homing PODXL/CD34-SELL. d. Neovascularization can interact with T cells via GRN-TNFRSF1B, CD34/PODXL-SELL, ICAM1-SPN, and FAM3C-PDCD1/CLEC2D pairs. Expression intensity was calculated by the geometric mean of an LR pair (a and c).

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